Sound design is probably a huge thing for a game simulating a space ship in such detail and I feel a lot of it will have to be communicated to the player via sound design as well. From heavier breathing as O2 in the surrounding atmosphere goes away to more muffled sounds as an atmosphere depletes or even just the sound of a flickering light. A lot can be done to push the user towards understanding their surroundings without being actually told directly. Or the sounds can be unusual and make the player check the systems based on that feedback.
I hope that sound design can be used to good effect in the game. A good soundtrack will do well, but I think ambient noise will play a much larger role in this.