It's called the 'wasteland' for a reason right? I think players should have the option to experiment with various drugs. Depending on what character build the player is using, and other conditions, drug use can vary in effects. A player with insomnia could craft a pipe and use their botany skill to forage for some bush weed. Concocting amphetamines using scavenged ingredients can be sold on the market, or used to bargain with one's life in combat. Magic mushrooms can be ingested and used to escape the wasteland for a little bit. Overdosing on uppers or downers is a possibility, too.